abstract：:Pneumococci are capable of vaccine escape by genetic recombination at the targeted capsular locus, significantly reducing long-term vaccine effectiveness. Recently, efforts have been redirected to understanding pneumococcal biology related to potential next-generation vaccine candidates. A variety of serotype-independ...

journal_title：Human vaccines & immunotherapeutics

authors： Abry MF,Kimenyi KM,Osowo FO,Odhiambo WO,Sewe SO,Kulohoma BW

更新日期：2015-01-01 00:00:00

abstract：:In recent years, nanomedicine has transformed many areas of traditional medicine, and enabled fresh insights into the prevention of previously difficult to treat diseases. An example of the transformative power of nanomedicine is a recent nano-vaccine against listeriosis, a serious bacterial infection affecting not on...

journal_title：Human vaccines & immunotherapeutics

authors： Calderon-Gonzalez R,Marradi M,Garcia I,Petrovsky N,Alvarez-Dominguez C

更新日期：2015-01-01 00:00:00

abstract：:MENK, a penta-peptide is considered as being involved in the regulatory feedback loop between the immune and neuroendocrine systems, with marked modulation of various functions of human immune cells. The aim of the present work was to investigate change of lymphocyte subpopulations in peripheral blood of 50 cancer pat...

journal_title：Human vaccines & immunotherapeutics

authors： Wang Q,Gao X,Yuan Z,Wang Z,Meng Y,Cao Y,Plotnikoff NP,Griffin N,Shan F

更新日期：2014-01-01 00:00:00

abstract：:The licensed meningococcal serogroup B vaccine, 4CMenB (Bexsero(®)), contains recombinant membrane proteins (rMenB) and outer membrane vesicles (OMV) of the New Zealand serogroup B strain. We investigated whether reducing the OMV and/or protein content influences 4CMenB immunogenicity and reactogenicity in healthy two...

journal_title：Human vaccines & immunotherapeutics

authors： Esposito S,Prymula R,Zuccotti GV,Xie F,Barone M,Dull PM,Toneatto D

更新日期：2014-01-01 00:00:00

abstract：:Similar features between the immune system of healthy elderly people and of younger individuals subjected to conditions of chronic immune activation are progressively being observed. This is raising the hypothesis that chronic immune activation may cause the premature aging of the immune system. Here we dissect this t...

journal_title：Human vaccines & immunotherapeutics

authors： Palma P,Rinaldi S,Cotugno N,Santilli V,Pahwa S,Rossi P,Cagigi A

更新日期：2014-01-01 00:00:00

abstract：:Health literacy skills are cognitive and social skills which determine the motivation and ability of individuals to gain access to, understand, and use information in ways which promote and maintain good health'. Patients use these literacy skills to critically analyze information; to allow them to exert greater contr...

journal_title：Human vaccines & immunotherapeutics

authors： Rowlands G

更新日期：2014-01-01 00:00:00

abstract：:In the clinical trials of the quadrivalent human papillomavirus (qHPV) vaccine, antibodies were measured by a competitive Luminex immunoassay (HPV-4 cLIA). A nine-valent HPV (9vHPV) vaccine targeting the types in the qHPV vaccine (HPV6/11/16/18), as well as 5 of the next most frequent HPV types found in cervical cance...

journal_title：Human vaccines & immunotherapeutics

authors： Roberts C,Green T,Hess E,Matys K,Brown MJ,Haupt RM,Luxembourg A,Vuocolo S,Saah A,Antonello J

更新日期：2014-01-01 00:00:00

abstract：:This study aims to quantify clinical and economic burden of rotavirus (RV) infection pre- and post-vaccine introduction in commercially insured and Medicaid populations. Beneficiaries with continuous enrollment for ≥6 months while <5 years of age were identified separately in commercial (2000-2010) and Medicaid (2002-...

journal_title：Human vaccines & immunotherapeutics

authors： Krishnarajah G,Demissie K,Lefebvre P,Gaur S,Sheng Duh M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The prevalence of occult hepatitis B (HB) infection (OBI) in HB-vaccinated diabetic children has not yet been tested. Here, we aimed to determine the prevalence of OBI among HB-vaccinated children and adolescents with insulin-dependent diabetes mellitus (IDDM). RESULTS:Eighty-seven (51.2%) children had a ti...

journal_title：Human vaccines & immunotherapeutics

authors： Elrashidy H,El-Didamony G,Elbahrawy A,Hashim A,Alashker A,Morsy MH,Elwassief A,Elmestikawy A,Abdallah AM,Mohammad AG,Mostafa M,George NM,Abdelhafeez H

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Over the past decade, there have been resurgences and large-scale outbreaks of mumps worldwide. Little evidence is available on the relationship between meteorological factors and the incidence of mumps. We aimed to explore the effects of meteorological factors on mumps incidence. METHODS:A Poisson regressi...

journal_title：Human vaccines & immunotherapeutics

authors： Yang Q,Yang Z,Ding H,Zhang X,Dong Z,Hu W,Liu X,Wang M,Hu G,Fu C

更新日期：2014-01-01 00:00:00

abstract：:Last decades, the number of routine childhood vaccinations has increased considerably, which consequently has led to multiple vaccine injections per consultation. Implementation of additional vaccines will probably lead to more than 2 vaccine injections per consult, which might be a barrier for parents to vaccinate th...

journal_title：Human vaccines & immunotherapeutics

authors： Kaaijk P,Kleijne DE,Knol MJ,Harmsen IA,Ophorst OJ,Rots NY

更新日期：2014-01-01 00:00:00

abstract：:Alzheimer disease is a devastating chronic disease without adequate therapy. More than 10 years ago, it was demonstrated in transgenic mouse models that vaccination may be a novel, disease-modifying therapy for Alzheimer. Subsequent clinical development has been a roller-coaster with some positive and many negative ne...

journal_title：Human vaccines & immunotherapeutics

authors： Fettelschoss A,Zabel F,Bachmann MF

更新日期：2014-01-01 00:00:00

abstract：:The relationship between obesity and vaccine efficacy is a serious issue. Previous studies have shown that vaccine efficacy is lower in the obese than in the non-obese. Here, we examined the influence of obesity on the efficacy of influenza vaccination using high fat diet (HFD) and regular fat diet (RFD) mice that wer...

journal_title：Human vaccines & immunotherapeutics

authors： Park HL,Shim SH,Lee EY,Cho W,Park S,Jeon HJ,Ahn SY,Kim H,Nam JH

更新日期：2014-01-01 00:00:00

abstract：:Despite a publicly funded immunization program and continuous promotional efforts, vaccine uptake for seasonal influenza in Quebec (Canada) remains under its goal of 80%. Missed opportunities can explain the low influenza vaccine rates among chronically ill children. To address that, demonstration projects using the l...

journal_title：Human vaccines & immunotherapeutics

authors： Dubé E,Gagnon D,Huot C,Paré R,Jacques S,Kossowski A,Quach C,Landry M

更新日期：2014-01-01 00:00:00

abstract：:Immunization can contribute to a dramatic reduction in number of vaccine-preventable diseases among children. The aim of this study is to investigate mothers' awareness about child vaccines and vaccination in Jordan. This study was a community-based, cross-sectional study that was performed at public places in Irbid C...

journal_title：Human vaccines & immunotherapeutics

authors： Masadeh MM,Alzoubi KH,Al-Azzam SI,Al-Agedi HS,Abu Rashid BE,Mukattash TL

更新日期：2014-01-01 00:00:00

abstract：:Despite recommendations for routine vaccination, HPV vaccination rates among adolescent females have remained low. The objective of this prospective cohort study was to determine whether clinician intention to recommend HPV vaccines predicts HPV vaccine series initiation among previously unvaccinated 11 to 18 year-old...

journal_title：Human vaccines & immunotherapeutics

authors： Feemster KA,Middleton M,Fiks AG,Winters S,Kinsman SB,Kahn JA

更新日期：2014-01-01 00:00:00

abstract：:A new live attenuated Japanese encephalitis chimeric virus vaccine (JE-CV) has been developed based on innovative technology to give protection against JE with an improved immunogenicity and safety profile. In this phase 3, observer-blind study, 274 children aged 12-24 months were randomized 1:1 to receive one dose of...

journal_title：Human vaccines & immunotherapeutics

authors： Kim DS,Houillon G,Jang GC,Cha SH,Choi SH,Lee J,Kim HM,Kim JH,Kang JH,Kim JH,Kim KH,Kim HS,Bang J,Naimi Z,Bosch-Castells V,Boaz M,Bouckenooghe A

更新日期：2014-01-01 00:00:00

abstract：:Maternal immunization holds tremendous promise to improve maternal and neonatal health for a number of infectious conditions. The unique susceptibilities of pregnant women to infectious conditions, as well as the ability of maternally-derived antibody to offer vital neonatal protection (via placental transfer), togeth...

journal_title：Human vaccines & immunotherapeutics

authors： Moniz MH,Beigi RH

更新日期：2014-01-01 00:00:00

abstract：:The durable long term clinical benefits seen for certain patients treated with immunotherapy agents has suggested there is significant therapeutic potential to be derived from these agents, as shown by the increasing prominence of this treatment strategy in upcoming clinical trials. There has been a renewed interest a...

journal_title：Human vaccines & immunotherapeutics

authors： O'Sullivan Coyne G,Gulley JL

更新日期：2014-01-01 00:00:00

abstract：:The combined diphtheria-tetanus-acellular pertussis-hepatitis B-poliomyelitis/Haemophilus influenza vaccine (DTPa-HBV-IPV/Hib: Infanrix™ hexa, GlaxoSmithKline Vaccines) is used for primary vaccination of infants in a range of schedules world-wide. Antibody persistence after 4 DTPa-HBV-IPV/Hib doses in the first 2 y of...

journal_title：Human vaccines & immunotherapeutics

authors： Silfverdal SA,Assudani D,Kuriyakose S,Van Der Meeren O

更新日期：2014-01-01 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that play an important role in stimulating an immune response of both CD4(+) T helper cells and CD8(+) cytotoxic T lymphocytes (CTLs). As such, DCs have been studied extensively in cancer immunotherapy for their capability to induce a specific anti...

journal_title：Human vaccines & immunotherapeutics

authors： Schneble EJ,Yu X,Wagner TE,Peoples GE

更新日期：2014-01-01 00:00:00

abstract：:Overexpressed tumor-self antigens represent the largest group of candidate vaccine targets. Those exhibiting a role in oncogenesis may be some of the least studied but perhaps most promising. This review considers this subset of self antigens by highlighting vaccine efforts for some of the better known members and foc...

journal_title：Human vaccines & immunotherapeutics

authors： Bright RK,Bright JD,Byrne JA

更新日期：2014-01-01 00:00:00

abstract：:In the last decade, peanut oral immunotherapy research has shown promise as an alternative treatment to avoidance in peanut-allergic patients. Research has not only focused on desensitization, but also on immunologic changes and sustained-tolerance. This article reviews the current literature and the historical backgr...

journal_title：Human vaccines & immunotherapeutics

authors： Deol S,Bird JA

更新日期：2014-01-01 00:00:00

abstract：:In a blinded randomized trial, preoperative receipt of the Merck V710 Staphylococcus aureus vaccine was associated with a higher mortality rate than placebo in patients who later developed postoperative S. aureus infections. Of the tested patients, all 12 V710 recipients (but only 1 of 13 placebo recipients) with unde...

journal_title：Human vaccines & immunotherapeutics

authors： McNeely TB,Shah NA,Fridman A,Joshi A,Hartzel JS,Keshari RS,Lupu F,DiNubile MJ

更新日期：2014-01-01 00:00:00

abstract：:We previously reported higher anti-HPV-16 and -18 immune responses induced by HPV-16/18 vaccine compared with HPV-6/11/16/18 vaccine at Month 7 (one month after completion of full vaccination series) in women aged 18-45 y in an observer-blind study NCT00423046; the differences of immune response magnitudes were mainta...

journal_title：Human vaccines & immunotherapeutics

authors： Einstein MH,Levin MJ,Chatterjee A,Chakhtoura N,Takacs P,Catteau G,Dessy FJ,Moris P,Lin L,Struyf F,Dubin G,HPV-010 Study Group.

更新日期：2014-01-01 00:00:00

abstract：:Studies assessing the economic burden of a mumps outbreak in a highly vaccinated population are limited. The Orange County Health Department (OCHD), New York State Department of Health (NYS DOH), and the Centers for Disease Control and Prevention conducted a mumps investigation in an affected village with a highly vac...

journal_title：Human vaccines & immunotherapeutics

authors： Kutty PK,Lawler J,Rausch-Phung E,Ortega-Sanchez IR,Goodell S,Schulte C,Pollock L,Valure B,Hudson J,Gallagher K,Blog D

更新日期：2014-01-01 00:00:00

abstract：:Influenza viruses cause annual winter epidemics globally and influenza vaccination is most effective way to prevent the disease or severe outcomes from the illness, especially in developing countries. However, the majority of the world's total production capacity of influenza vaccine is concentrated in several large m...

journal_title：Human vaccines & immunotherapeutics

authors： Liu Y,Wu JY,Wang X,Chen JT,Xia M,Hu W,Zou Y,Yin WD

更新日期：2014-01-01 00:00:00

abstract：:The objectives of this study were to estimate incidence density rates (IDR) of herpes zoster (HZ) and to analyze the association with sociodemographic characteristics and selected chronic medical conditions. The study cohort consisted of the adult population included in the Public Health System of the Autonomous Commu...

journal_title：Human vaccines & immunotherapeutics

authors： Esteban-Vasallo MD,Domínguez-Berjón MF,Gil-Prieto R,Astray-Mochales J,Gil de Miguel A

更新日期：2014-01-01 00:00:00

abstract：:Although pancreatic cancer is but the eleventh most prevalent cancer in the US, it is predicted that of all the patients newly diagnosed with this disease in 2014, only 27% will still be alive at the end of the first year and only 6% will make it past 5 years. The choice of chemotherapy in the treatment of pancreatic ...

journal_title：Human vaccines & immunotherapeutics

authors： Hartley ML,Bade NA,Prins PA,Ampie L,Marshall JL

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:We studied completeness and timeliness of vaccination and determinants for low and delayed uptake in children born between 2008 and 2009 in Zhejiang province in eastern China. METHODS:We used data from a cross-sectional cluster survey conducted in 2011, which included 1146 children born from 1 Jan 2008 to 3...

journal_title：Human vaccines & immunotherapeutics

authors： Hu Y,Chen Y,Guo J,Tang X,Shen L

更新日期：2014-01-01 00:00:00

abstract：:Salmonella enterica serovar Paratyphi A (S. Paratyphi A) is a human restricted pathogen that can cause systemic infection (paratyphoid fever) with recently increased incidence particularly in developing countries. Currently there is no licensed vaccine for prevention of infection from S. Paratyphi A. In this study the...

journal_title：Human vaccines & immunotherapeutics

authors： Ali A,An SJ,Cui C,Haque A,Carbis R

更新日期：2014-01-01 00:00:00

abstract：:Human papillomavirus (HPV) vaccine uptake among 18-26 y old women varies by geographic region in the US. However, little is known about regional variations in vaccination among girls who are in the vaccine's targeted age groups. Regional variation in HPV vaccination among female adolescents (9-17 y old) was examined u...

journal_title：Human vaccines & immunotherapeutics

authors： Hirth JM,Rahman M,Smith JS,Berenson AB

更新日期：2014-01-01 00:00:00

abstract：:This survey study compared pre- and post-pandemic knowledge, attitudes, beliefs, and intended behaviors of pregnant women regarding influenza vaccination (seasonal and/or pandemic) during pregnancy in order to determine key factors influencing their decision to adhere to influenza vaccine recommendations. Only 36% of ...

journal_title：Human vaccines & immunotherapeutics

authors： Halperin BA,MacKinnon-Cameron D,McNeil S,Kalil J,Halperin SA

更新日期：2014-01-01 00:00:00

abstract：:Individuals infected with human immunodeficiency virus (HIV) have excess risk of developing human papillomavirus (HPV)-related disease. A substantial fraction of HPV-associated cancers is caused by HPV serotypes not included in the currently available vaccines. Among healthy women, both Cervarix(®) (HPV-16/18, GlaxoSm...

journal_title：Human vaccines & immunotherapeutics

authors： Toft L,Tolstrup M,Müller M,Sehr P,Bonde J,Storgaard M,Østergaard L,Søgaard OS

更新日期：2014-01-01 00:00:00

abstract：:Immunization against pertussis, influenza, and rubella reduces morbidity and mortality in pregnant women and their offspring. Health care professionals (HCPs) caring for women perinatally are uniquely placed to reduce maternal vaccine preventable diseases (VPDs). Despite guidelines recommending immunization during the...

journal_title：Human vaccines & immunotherapeutics

authors： Webb H,Street J,Marshall H

更新日期：2014-01-01 00:00:00

abstract：:Psoriasis is a chronic, immune skin disease associated with significant morbidity. Development of psoriasis is influenced by numerous genes, one allele is HLA-CW*0602. Other genes and single nucleotide polymorphisms affect immunologic pathways and antimicrobial peptide synthesis. Dendritic cells initiate psoriasis by ...

journal_title：Human vaccines & immunotherapeutics

authors： Kaffenberger BH,Lee GL,Tyler K,Chan DV,Jarjour W,Ariza ME,Williams MV,Wong HK

更新日期：2014-01-01 00:00:00

abstract：:Cellular immunotherapy can be an effective adjuvant treatment for multiple myeloma (MM), as demonstrated by induction of durable remissions after allogeneic stem cell transplantation. However, anti-myeloma immunity is often hampered by suppressive mechanisms in the tumor micro-environment resulting in relapse or disea...

journal_title：Human vaccines & immunotherapeutics

authors： Roeven MW,Hobo W,Schaap N,Dolstra H

更新日期：2014-01-01 00:00:00

abstract：:Haemophilus influenzae type b (Hib) and 7-valent pneumococcal (PCV7) vaccines both became recommended in Japan in 2010. In this study, cytokine production was investigated in peripheral blood mononuclear cells (PBMCs) cultures stimulated with diphtheria and tetanus toxoids combined with acellular pertussis vaccine (DP...

journal_title：Human vaccines & immunotherapeutics

authors： Kashiwagi Y,Miyata A,Kumagai T,Maehara K,Suzuki E,Nagai T,Ozaki T,Nishimura N,Okada K,Kawashima H,Nakayama T

更新日期：2014-01-01 00:00:00

abstract：:Paralytic poliomyelitis is a disease that became a public health issue at the beginning of the twentieth century and was more or less eliminated in developed countries by the early 1970s. The Global Polio Eradication Initiative of WHO has now eradicated endemic polio from all but three countries although re-introducti...

journal_title：Human vaccines & immunotherapeutics

authors： Minor P

更新日期：2014-01-01 00:00:00

abstract：:Research on innate immune signaling and regulation has recently focused on pathogen recognition receptors (PRRs) and their signaling pathways. Members of PRRs sense diverse microbial invasions or danger signals, and initiate innate immune signaling pathways, leading to proinflammatory cytokines production, which, in t...

journal_title：Human vaccines & immunotherapeutics

authors： Cui J,Chen Y,Wang HY,Wang RF

更新日期：2014-01-01 00:00:00